Treatment Strategy In Hodgkins Disease

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Strat Gie Th Rapeutique Dans La Maladie De Hodgkin

Author : Reiner Somers
ISBN : 0861962265
Genre : Hodgkin's disease
File Size : 23.9 MB
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Presents proceedings of the Paris International Workshop & Symposium held on 28 to 30, June 1989.
Category: Hodgkin's disease

Hodgkin Lymphoma

Author : Andreas Engert
ISBN : 3642127800
Genre : Medical
File Size : 51.88 MB
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This book provides a well-illustrated, comprehensive, and up-to-date account of Hodgkin lymphoma. Epidemiology, pathogenesis, and the role of the microenvironment are examined in detail. The initial clinical evaluation and use of staging systems are fully discussed, and prognostic factors are carefully considered. The various treatment options for first-line and relapsed Hodgkin lymphoma are presented, including the newly available treatments for recurrent disease and the management required in special clinical circumstances. Given the very high cure rates and the young age of many patients, there is an increasing need to develop better individually tailored treatment strategies that will help to avoid both early and late side-effects of treatment. Such strategies receive due attention, and clear guidance is provided on the handling of Hodgkin survivors. This book will be of great value to hematologists, oncologists, and all others with an interest in Hodgkin lymphoma.
Category: Medical

Non Hodgkin S Lymphoma

Author : National Guideline Alliance (Great Britain)
ISBN : 1473119995
Genre :
File Size : 40.48 MB
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Non-Hodgkin's lymphoma is the sixth most common cancer in the UK. There are many different subtypes of the disease, with markedly different clinical courses and requirements for therapy. Diagnosing non-Hodgkin's lymphoma and the precise subtype is challenging, and optimising the diagnostic process is central to improved management. Significant improvements in our understanding of the biology of non-Hodgkin's lymphoma have contributed to improved diagnosis and also allowed for more targeted therapies. The treatment of non-Hodgkin's lymphoma has been a beacon for the development of specific treatment strategies (now applied to many other forms of cancer), but paradoxically there is a paucity of large randomised clinical trials to define best practice in treating the various subtypes. As a consequence there are considerable differences between centres and countries in the ways in which some subtypes of the disease are diagnosed and managed. There have been some improvements in outcome for people with non-Hodgkin's lymphoma in the last decade, but these have been relatively modest and there is still a need for improvement. This is a rapidly developing field, with a number of new therapies proving to be exciting in initial studies. It is too soon, however, to judge their long-term impact, and ongoing assessment of these new agents compared with standard therapy will be needed. This guideline aims to facilitate standardisation of practice in treating non-Hodgkin's lymphoma. But because of the rapid development of new therapies as a result of improved understanding of the biology of the disease, continual re-evaluation will be essential.
Category:

Hodgkin Lymphoma

Author : Andreas Engert
ISBN : 9783030324827
Genre : Medical
File Size : 50.29 MB
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This book, now in its third edition, examines the current treatment options for first-line, relapsed, and refractory Hodgkin lymphoma and the appropriate management in special clinical circumstances, including in the elderly, pregnant women, and those with nodular lymphocyte-predominant disease (NLPHL). Careful attention is devoted to the emerging individually tailored treatment strategies, including checkpoint inhibition, that are especially appealing given their potential to reduce early and late treatment side effects in this generally young patient population. In addition, clear guidance is provided on the management of Hodgkin survivors. Other topics addressed include epidemiology, pathogenesis, the role of the microenvironment, initial clinical evaluation, imaging diagnosis, use of staging systems, and prognostic factors. The new edition of Hodgkin Lymphoma: A Comprehensive Overview has been revised and updated by key opinion leaders to reflect recent progress in the field. It will be of great value to hematologists, oncologists, and all others with an interest in Hodgkin lymphoma.
Category: Medical

Non Hodgkin S Lymphoma In Childhood And Adolescence

Author : Oussama Abla
ISBN : 3030117685
Genre : Medical
File Size : 40.62 MB
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This text provides a state-of-the-art overview on Non-Hodgkin's lymphoma (NHL) in children and adolescents. The volume is divided into seven sections, each of which focuses on a critical component of pediatric NHL, including history and epidemiology, pathology and molecular biology, disease evaluation and response, common and rare sub-types of NHL, and current and novel treatment strategies. The text also comprehensively reviews the late effects of treatment, quality of patient life, and NHL treatment in countries with limited resources. Written by experts in the field, Non-Hodgkin's Lymphoma in Childhood and Adolescence is a valuable resource for clinicians and practitioners who treat children and adolescents with NHL.
Category: Medical

Rare Lymphomas

Author : Martin Dreyling
ISBN : 9783642395901
Genre : Medical
File Size : 76.58 MB
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After a decade of tremendous progress in the diagnostic and therapeutic approaches to malignant lymphoma, optimal treatment strategies are now based not only on accurate diagnosis but also on thorough evaluation of clinical and molecular risk factors. Even more importantly, molecular targeted approaches have been shown to be effective in the treatment of distinct lymphoma subtypes. Against this background, clinical management of especially the rare lymphomas remains a challenge for the general oncologist. This book provides a comprehensive overview of current treatment strategies in these rare lymphoma subtypes. Experts in the field from around the world describe histomorphology in a clinically relevant manner, consider the role of risk factors in detail, and discuss the spectrum of therapeutic approaches. Special emphasis is placed on the translation of molecular science into clinical care, and a disease-specific algorithm is proposed for each entity.
Category: Medical

Malignant Lymphomas Including Hodgkin S Disease Diagnosis Management And Special Problems

Author : Bruce W. Dana
ISBN : 9781461530848
Genre : Medical
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This volume is intended to present an eclectic selection of informative reviews on aspects of the malignant lymphomas, including Hodgkin's disease. The choice of suitable review topics in this field is made hazardous by several facts. First, the growth of insight into basic mechanisms of lymphomagenesis is explosive, as is the expansion of our understanding of the need for precise morphologic classification of these diseases. Second, new therapeutic agents, cytotoxic and biologic, as well as new drug delivery strategies, are appearing with remarkable frequency. Finally, old "standard" approaches, such as the staging laparotomy for Hodgkin's disease, are being reconsidered and deserve attention in an up-to-date collection of papers. The 10 reviews presented here fall generally into three categories. First, the optimal diagnostic and therapeutic approaches to Hodgkin's disease are considered by Mark Leibenhaut, who reviews the status of the diagnostic staging laparotomy, and by Philip Bierman, who discusses his thoughts on the timing of high-dose treatment with bone marrow transplantation for this disease. There follow four reviews of current management of specific histologic subtypes of malignant lymphoma. First, Velasquez reviews prognostic factors in both intermediate and high grade lymphomas. Miller and Dahlberg review and update the Southwest Oncology Group experience in developing curative cytotoxic combination therapies for diffuse large-cell lymphomas. Lastly, optimal therapy for two kinds of high grade lymphoma are presented. Butler and Hainsworth describe the Vanderbilt experience with diffuse small noncleaved cell lymphoma and Picozzi reviews lymphoblastic lymphoma.
Category: Medical

Response Adapted Therapy In Hodgkin S Lymphoma

Author : TS Ganesan
ISBN : OCLC:1250399593
Genre :
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CONTEXT: Interim PET-CT guided therapy has emerged as one standard approaches for Hodgkinu2019s Lymphoma (HL). We had conducted a phase II study and reported reported early results with 2 year follow up(Ann Oncol. 2015 Jun;26(6):1170-4) and now we present our results with more mature 5-year follow up.DESIGN: Phase II, single-arm, single center study conducted between 2011 and 2013. Trial registration: CTRI/2012/06/002741(http://www.ctri.nic.in).SETTING: Tertiary cancer center in South India.PATIENTS: Newly-diagnosed patients with aHL.INTERVENTIONS: Patients received 2 cycles ABVD then PET-2; if negative (Deauville score, DS 1-3) they continued 4 additional cycles of ABVD and if positive (DS 4, 5) they received 4 cycles of Escalated BEACOPPMAIN OUTCOMES MEASURES: Primary end point was event free survival (EFS) u2013 from start of therapy till event (relapse after initial response, or progression from PR or death). The secondary end points were overall survival and toxicity of EB.RESULTS: Fifty patients [median age: 28 years, 12-60; 78% males; Stages: IIB: 3 (6%), III: 29 (58%) and IV: 18 (36%); High risk IPS score 4-7: 16 (32%)] were included and 49 had interim PET study [positive 8 (16%), negative 41]. EB was started in 7/8 patients with positive scans, 5 (of 7) achieved complete remission 4 remain event-free till now. Among PET-2-ve patients (N=41), 34 remain event free. After a median follow up of 66 months (3-89), the estimated 5-yr EFS and OS was 77% and 85% respectively for the entire cohort of 50 patients. For the PET-2 positive patients, 5-yr EFS and OS was 50% and 62% and for the PET-2 negative group it was 82% and 89% respectively.CONCLUSIONS: The results of response-adapted escalation treatment strategy in aHL are sustained and the outcomes of PET-2 positive patients are improved. Outcomes in PET-2 negative patients are lower than those reported in retrospective analyses but comparable to similar prospective studies.
Category:

Trends In Hodgkin S Disease Research

Author : Beverley C. Heinz
ISBN : 1594543402
Genre : Medical
File Size : 21.23 MB
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Hodgkin's disease, sometimes called Hodgkin's lymphoma, is a cancer that starts in lymphatic tissue. Lymphatic tissue includes the lymph nodes and related organs that are part of the body's immune and blood-forming systems. The lymph nodes are small, bean-shaped organs found underneath the skin in the neck, underarm, and groin. They are also found in many other places in the body such as inside the chest, abdomen, and pelvis. Lymph nodes make and store infection-fighting white blood cells, called lymphocytes. They are connected throughout the body by lymph vessels (narrow tubes similar to blood vessels). These lymph vessels carry a colourless, watery fluid (lymphatic fluid) that contains lymphocytes. Eventually the lymphatic fluid is emptied into the blood vessels in the left upper chest. There are 5 different types of Hodgkin's lymphoma: Nodular sclerosing Hodgkin's lymphoma; Mixed cellularity Hodgkin's lymphoma; Lymphocyte depletion Hodgkin's lymphoma; Lymphocyte-rich classical Hodgkin's lymphoma; Nodular lymphocyte-predominant Hodgkin's lymphoma. This volume examines and presents leading-edge research in this field.
Category: Medical

New Aspects In The Diagnosis And Treatment Of Hodgkin S Disease

Author : Volker Diehl
ISBN : 9783642837814
Genre : Medical
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In the field of Hodgkin's lymphoma, many new data have been collected during the last decade both on the cell of origin of this disease and on more effective therapies to cure the majority of pa tients even in the advanced stages. Therefore, it seems to be justi fied to compile these new data in a special volume of Recent Re sults in Cancer Research. This volume summarizes the contribu tions presented at the First International Symposium on Hodgkin's Disease that took place in Cologne (FRG) on October 2-3, 1988. There is little doubt that the Hodgkin and Reed-Sternberg (H and RS) cells and their variants represent the malignant population in Hodgkin's lymphoma; however, there is still a fierce debate as to the possible cell of origin of Hand RS cells. Many of the problems confounding earlier research into this question were related to the difficulty or virtual impossibility, of obtaining purified populations of Hand RS cells. Most of the recent progress stems from the establishment of permanent cell lines of Hand RS cells in culture.
Category: Medical

Hodgkin S Lymphoma An Issue Of Hematology Oncology

Author : Volker Diehl
ISBN : 9780323266611
Genre : Medical
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This issue of Hematology/Oncology Clinics is focused on Hodgkin's Lymphoma and covers such topics as First HRS-cell line L428 and the detection of the CD-30 Antigen , “Normal“ CD30-B-lymphocytes, CD-30-Antigen, Combination-Chemo-Radiotherapy, Early intensification (escBEACOPP), Customized/Targeted Therapy, and more.
Category: Medical

Hodgkin Lymphoma

Author : Andreas Engert
ISBN : 3642127819
Genre : Medical
File Size : 25.45 MB
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This book provides a well-illustrated, comprehensive, and up-to-date account of Hodgkin lymphoma. Epidemiology, pathogenesis, and the role of the microenvironment are examined in detail. The initial clinical evaluation and use of staging systems are fully discussed, and prognostic factors are carefully considered. The various treatment options for first-line and relapsed Hodgkin lymphoma are presented, including the newly available treatments for recurrent disease and the management required in special clinical circumstances. Given the very high cure rates and the young age of many patients, there is an increasing need to develop better individually tailored treatment strategies that will help to avoid both early and late side-effects of treatment. Such strategies receive due attention, and clear guidance is provided on the handling of Hodgkin survivors. This book will be of great value to hematologists, oncologists, and all others with an interest in Hodgkin lymphoma.
Category: Medical

Hodgkin S Disease In Children

Author : W.A. Kamps
ISBN : 9781461317395
Genre : Medical
File Size : 79.98 MB
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Where do you begin to look for a recent, authoritative article on the diagnosis or management of particular malignancy? The few general oncol ogy textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often prelimin ary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung can cer, genitourinary cancer, pediatric oncology, etc. Second, by asking emin ent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.
Category: Medical

Hodgkin Lymphoma

Author : Richard Hoppe
ISBN : 078176422X
Genre : Medical
File Size : 67.18 MB
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The definitive text on Hodgkin lymphoma is now in its thoroughly revised, updated Second Edition. More than 100 recognized authorities from all parts of the world provide comprehensive, current information on every aspect of Hodgkin lymphoma, including etiology, epidemiology, biology, pathology, evaluation, staging, treatment, and follow-up. This edition describes the increased use of PET scanning in staging and follow-up. Chapters discuss current treatment options—including combination chemotherapy, radiation therapy, novel treatment techniques, and hematopoietic stem cell transplantation—and offer guidelines for treatment selection. Full consideration is given to late effects of therapy and clinical trials for assessing quality of life in patients. This edition includes complete access to the fully searchable online text of the entire book with all the images at www.hodgkinlymphomasolution.com.
Category: Medical

Everyone S Guide To Cancer Therapy

Author : Dr. Andrew Ko
ISBN : 0740768573
Genre : Health & Fitness
File Size : 27.33 MB
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Revised 5th Edition Praise for the first edition of Everyone's Guide to Cancer Therapy: How Cancer Is Diagnosed, Treated, and Managed Day to Day: A landmark book . . . So much of what the cancer patient must know to make informed decisions. --Publishers Weekly * A completely revised and accessible guide created by more than 100 esteemed oncologists for the millions of people whose lives are affected by cancer. The Centers for Disease Control reports that more than 20 million people in the U.S. are currently diagnosed with cancer, and 1.4 million people are expected to be diagnosed in the coming year. For the millions confronting cancer's many challenges, Everyone's Guide to Cancer Therapy: How Cancer Is Diagnosed, Treated, and Managed Day to Day relies on an esteemed panel of oncology specialists--more than 100 strong, and each experts in their fields-to completely update this definitive cancer resource. Equally informative and accessible, this comprehensive book navigates cancer patients and their caregivers through diagnosis, treatment, and supportive care. Every chapter has been methodically updated to include the latest medical breakthroughs and advice concerning cancer treatment, including: * Information on recently approved targeted therapies for various cancer types * The newest strategies in cancer diagnosis and prevention * Cancer biology: translating scientific discoveries into meaningful advances for patients * Supportive care and complementary approaches
Category: Health & Fitness

Radiation Therapy For Extranodal Lymphomas

Author : Keisuke Sasai
ISBN : 9784431564355
Genre : Medical
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This book is devoted to sharing the knowledge and experience of expert radiation therapy (RT) for extranodal lymphomas. For that purpose, the authors provide clinical-pathological information, precise RT techniques, and treatment results, i.e., disease control and survival, of all extranodal lymphomas. Over the past 10 years, specific techniques have been updated, from 3-dimensional conformal RT to intensity modulated RT / volumetric-modulated arc therapy. Precise targeting such as image-guided RT and active breathing control are now capable of treating lymphoma lesions that shift with respiration or peristalsis. This book, serving as a guide, provides the necessary knowledge for radiation oncology, practice, and planning involving the RT techniques of treating extranodal lymphomas. In addition, it equips oncologists, hematologists, and medical oncologists to refer patients with extranodal lymphomas to radiation oncologists for appropriate treatment in a timely manner. Therefore this volume will greatly benefit all oncologists, including radiation and medical oncologists, as well as hematologists.
Category: Medical

Hodgkin S And Non Hodgkin S Lymphoma

Author : John P. Leonard
ISBN : 0387293469
Genre : Medical
File Size : 42.89 MB
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In recent years a dramatic increase in knowledge of the biology of the lymphomas has been accompanied by the emergence of new treatments offering improvements in efficacy and reduction in toxicity. In this volume an internationally recognized group of experts review relevant aspects of the biology, diagnosis and management, with particular emphasis on the emerging data available for this disease.
Category: Medical

Malignant Lymphomas And Hodgkin S Disease Experimental And Therapeutic Advances

Author : Franco Cavalli
ISBN : 9781461326076
Genre : Medical
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Malignant lymphomas remain a fascinating research topic for clinicians as well as basic scientists. Rapidly increasing technical sophistication, ex panded knowledge and broader implications of new findings underline the need for a forum to integrate the latest developments in the multiple areas involved in the challenging study of lymphoid malignancies. This volume includes contributions of renowned experts and is based on a selection of papers presented at the Second International Conference on Malignant Lymphomas that was held in Lugano, Switzerland, in June 1984. Updated information is provided on various experimental fields including cell biolo gy, immunology, genetics and cell biochemistry. Particular attention has been given to special clinical entities such as the lymphomas associated with the Acquired Immune Deficiency Syndrome. Recent advances in the treat of Hodgkin's disease, ncin-Hodgkin's lymphomas and childhood lym ment phomas are highlighted with emphasis on growing experience with new therapeutic approaches including monoclonal antibodies and bone marrow transplantation. The contents of the volume reflect and translate numerous avenues of exploration. While there might be some unavoidable overlap, most appear essentially complementary. The intent of the Program Committee of the Second International Conference on Malignant Lymphomas was to promote further interactions between all those who are devoting major efforts to elucidate the nature of these diseases or their optimal therapy. This volume will hopefully amplify this objective. The Editors wish to thank the contributors for delivering the manuscripts on schedule.
Category: Medical

Etiology Of Hodgkin S Disease

Author : Ruth F. Jarrett
ISBN : 9781461303398
Genre : Medical
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This volume reports the proceedings of a NATO Advanced Workshop held at Cameron House Hotel, Loch Lomond, Scotland, from May 2 - 5, 1994. The major impetus for this workshop was the realisation, over the past 7 years, that the Epstein-Barr virus is associated with a proportion of cases of Hodgkin's disease and is likely to play an aetiological role. There were four main aims of the workshop: first, to discuss the recent findings in relation to Epstein Barr virus and the aetiology of Hodgkin's disease; second, to relate these data to the epidemiology of Hodgkin's disease; third, to discuss other potential aetiological factors and finally, to discuss future directions for research into Hodgkin's disease. Leading experts in the field have contributed chapters to this volume. There is some overlap among chapters, particularly regarding Epstein-Barr virus, thereby allowing different groups to express views on similar topics. Perhaps, however, the most surprising feature of the workshop was the lack of controversy regarding the role of Epstein-Barr virus in Hodgkin's disease, an association that was treated with great scepticism at the beginning of the decade. The first three chapters, by Alexander, Taylor et al., and Levine el al., discuss the epidemiology of Hodgkin's disease with particular attention to clustering and genetic susceptibility. These chapters represent the first attempt to bring together epidemiological and molecular studies in Hodgkin's disease.
Category: Medical