The Hepatobiliary System

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The Hepatobiliary System

Author : W. Taylor
ISBN : 9781461589006
Genre : Medical
File Size : 36.12 MB
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A volume on the biliary system appeared in 1965, based on a symposium of the NATO Advanced Institute held in September, 1963, in Newcastle upon Tyne in England. It soon became an authorita tive text on the problems of the biliary tract and, for instance, the discussion on the biliary secretion of organic anions, organic cations and inorganic ions were classic references. The worn pages of the volume in many libraries, including my own, bespeak its usefulness over ten long years. The initiative and energy of the Director of the first Institute have to be admired, even more so since he was able to assemble a Second Institute in Aalborg, Denmark, in 1975. His wisdom is reflected in the selection of the subjects discussed. The comparison between the two volumes tells something about the advancement in the time interval in knowledge about liver and biliary tract diseases, about the turnover of researchers interested in the liver and its diseases, and also about the present philosophy in biologic science. For this com parison, this volume is particularly suited because, in contrast to many other recent conferences, the more leisurely pace of the NATO Institutes permits more comprehensive but still scholarly reviews of the problems. The foreword of the first volume, written by my colleague, the late Harry Sobotka, expresses his, now dated, astonishment about the progress of knowledge of biology of the bile, so much less accessible to study than urine.
Category: Medical

Diffusion Weighted Imaging Of The Hepatobiliary System

Author : Celso Matos
ISBN : 331962976X
Genre : Medical
File Size : 43.6 MB
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This book presents the core principles and technical aspects of Diffusion Weighted Imaging (DWI), as well as pearls and pitfalls concerning the imaging technique’s application to the hepatobiliary system. All technical aspects and clinical applications discussed focus on the related anatomical region and its pathologies. Given that magnetic resonance physics is complex and can be cumbersome to learn, the volume editors and authors have made it as simple and practical as possible. Accordingly, tables related to technical details (imaging protocols, artefacts, and optimization techniques) are provided for each chapter. Though DWI is frequently used in the abdomen and pelvis, its clinical role is still evolving, especially for the diagnostic workup of oncologic patients. Although certain efforts have been undertaken to standardize and provide imaging guidelines for different clinical indications, the standardisation and clinical validation of quantitative DWI-related biomarkers are still works in progress. Addressing this gap, the book offers a useful tool for radiologists with a particular interest in abdominal radiology, as well as for radiology residents.
Category: Medical

Biliary Tract Radiology

Author : Plinio Rossi
ISBN : 9783642603433
Genre : Medical
File Size : 41.22 MB
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This book, edited by Prof. PLINIO ROSSI, an internationally well-known expert in biliary tract radiology, provides in 31 chapters a very comprehensive update on both diagnostic and therapeutic radiology of the biliary tract. First, a very complete and interesting overview of the normal morphology of the ana tomical area is presented by an anatomist, a radiologist, and a surgeon. This is followed by a discussion not only of the well-known and accepted imaging modalities, but also of the newer ones such as, magnetic resonance imaging and endoluminal and laparoscopic ultra sound. The book thus illustrates very nicely the diversity of diagnostic radiological tech niques that are currently available. Considerable technical progress and remarkable new insights in biliary tract radiology have been achieved in the field of the radiological interventional approach during recent years. Therefore, much emphasis has been placed in this book on the therapeutic possibili ties of the radiologist using the percutaneous minimally invasive approach for the treat ment of the various pathological conditions of the biliary tract. It is most impressive to note the substantial progress in terms of patient comfort achieved by using the percutaneous as compared to the surgical methods. These new methods also result in shorter hospitalization times and thereby help to reduce health care costs. This book provides the interested reader with a fascinating and very complete over view of these new procedures.
Category: Medical

Bile Acids And The Hepatobiliary System

Author : G. Paumgartner
ISBN : UOM:39015029111088
Genre : Medical
File Size : 26.8 MB
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Bile acids have recently found application in the treatment of hepatobiliary diseases. Chenodeoxycholic acid and ursodeoxycholic acid have proved to be effective agents for the dissolution of cholesterol gallstones, and ursodeoxycholic acid has been shown to have beneficial effects in patients with chronic cholestatic liver disease such as primary biliary cirrhosis or primary sclerosing cholangitis. The question of the long-term benefit for the patient remains open and the mechanism of action is still unclear. As a consequence, much basic and clinical research is being conducted on bile acid therapy. The XIIth International Bile Acid Meeting brought together researchers and clinicians from around the world, and was dedicated to basic and clinical aspects of the use of bile acids in the therapy of hepatobiliary disease.
Category: Medical

Diseases Of The Liver And Biliary System In Children

Author : Deirdre A. Kelly
ISBN : 1444300547
Genre : Medical
File Size : 37.6 MB
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“An excellent up-to-date comprehensive and practical text book dealing with all aspects of paediatric hepatobiliary disease. It will be useful to both generalists and specialists as it is clinically focused with a problem-solving approach and should be useful for day-to-day as well as more esoteric clinical problems. I found it useful in my general paediatric practice and my trainees have also found it useful. It is very practical with a diagnostic approach and lots of tables and clinical pathways to follow when confronted with day-to-day clinical problems. I have road-tested it in real life with good effect.” - Judging Panel, 2004 BMA Medical Book Competition Diseases of the Liver and Biliary System in Children, Third Edition provides a practical approach to the diagnosis and management of paediatric liver diseases, highlighting the importance of multidisciplinary team working and holistic management of the child and family. This fully revised edition has also been updated to cover recent advances in paediatric hepatology. It includes new chapters describing the effects of liver disease in pregnancy on mother and child through to adolescence. With increasing numbers of young people surviving into adult life this edition addresses the importance of managing adolescent transition effectively. Trainees, practising paediatric gastroenterologists and hepatologists will welcome the practical approach outlined in this text, while other healthcare professionals involved in the management of liver disease in children will find it an accessible and comprehensive reference.
Category: Medical

Practical Interventional Radiology Of The Hepatobiliary System And Gastrointestinal Tract

Author : Andy Adam
ISBN : 0340551666
Genre : Medical
File Size : 59.2 MB
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This is an up-to-date guide to interventional techniques in the hepatobiliary system and gastrointestinal tract. Practicing interventional radiologists seeking to improve their technique in this area will find it invaluable. It is illustrated with a large number of line diagrams as well as relevant radiographs. The contributors have been selected not only for their eminence in this field, but also because they are all practicing and enthusiastic interventional radiologists with a deep understanding of the instruments and techniques they employ. Each chapter is divided into four sections dealing with intervention in the bile ducts and gall bladder, percutaneous biopsy and abscess drainage, oesophageal and gastrointestinal intervention, and angiographic intervention. The authors have given emphasis to practical issues of technique and equipment, complications and their avoidance.
Category: Medical

The Biliary System

Author : David Q.-H. Wang
ISBN : 9781615047383
Genre : Medical
File Size : 56.2 MB
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The liver is a vital organ involved in numerous metabolic processes such as cholesterol and bile acid metabolism, biliary lipid secretion, and bile formation. Cholesterol balance across the liver has a crucial effect on influencing plasma total and LDL cholesterol levels and biliary cholesterol concentrations. Cholesterol and bile acid biosyntheses are primarily modulated by negative feedback regulatory mechanisms through the sterol regulatory element-binding protein isoform 2 (SREBP-2) and the farnesoid X receptor (FXR) pathways, respectively. The conversion of cholesterol to bile acids in the liver can balance the fecal excretion of bile acids, which is an important route for the removal of cholesterol from the body. Bile formation begins in the bile canaliculi, and maintenance of the enterohepatic circulation of bile acids results in a continuous secretion of bile. Hepatic secretion of biliary lipids is determined mainly by a group of ATP-binding cassette (ABC) transporters that are located on the canalicular membrane of hepatocytes, which are regulated by various nuclear receptors. Bile acids promote bile flow by their osmotic effects. Also, they are essential for the intestinal absorption of cholesterol, fatty acids, and fat-soluble vitamins and play an important role in aiding the digestion of dietary fat. Bile acids function as signaling molecules and anti-inflammatory agents to regulate lipid, glucose, and energy metabolism by rapidly activating nuclear receptors and cell signaling pathways. This eBook summarizes the progress in the molecular and cellular mechanisms of cholesterol and bile acid metabolism and the physical-chemistry of biliary lipids, with emphasis on biliary lipid metabolism that is regulated by nuclear receptors in the hepatobiliary system.
Category: Medical

Sherlock S Diseases Of The Liver And Biliary System

Author : James S. Dooley
ISBN : 9781119237549
Genre : Medical
File Size : 61.76 MB
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A new, fully updated edition of the world’s most famous book on liver diseases—with updating of all areas and inclusion of new specific topics, by internationally renowned specialists This brand new edition of the classic book on hepatology provides a concise, clearly presented and well-structured review across the whole spectrum of hepatobiliary diseases by some of the world’s leading hepatologists and hepatobiliary specialists. Where many other hepatology textbooks provide detailed accounts of basic science and clinical management, Sherlock's Diseases of the Liver and Biliary System, 13th Edition takes a different approach. Concentrating on the clinical decisions to be taken and the relevant supporting data, it is written and edited to maintain Sheila Sherlock's unique approach, in particular the clarity and layout of the text, and the explanatory figures and tables. The book is thus concise, highly accessible, and generously illustrated with over 700 attractive color figures. There is a pithy approach to each disease based both on evidence and on the authors’ experience, the hallmark of this book. Based on these elements, the 12th edition was awarded first prize in the 2012 British Medical Association Book Awards in the Internal Medicine category. Sherlock's Diseases of the Liver and Biliary System begins by introducing the anatomy and function of the liver to readers, continuing then with in-depth coverage of liver biopsy techniques and interpretation, and fibrogenesis and its assessment. There are then chapters on all aspects of liver and biliary disease including acute liver failure, cirrhosis, portal hypertension, hepatic encephalopathy, ascites, hepatitis B and C, alcohol and the liver, non-alcoholic fatty liver disease, drug related liver reactions, cholestatic, autoimmune and genetic liver diseases, benign and malignant tumours and not least liver transplantation. There are also chapters on the liver in pregnancy, in the neonate, infancy and childhood, in systemic diseases and in infections. This new edition also features four new individual chapters focusing on coagulation, non-invasive assessment of fibrosis and cirrhosis; vascular diseases of the liver and portal vein thrombosis, and nutrition in liver disease. Digital downloads of the figures from this edition are offered on a companion website. Internationally recognized and loved, world-renowned hepatology book, first published in 1955 Takes a one-of-a-kind, clinical approach maintaining Sheila Sherlock’s clarity and legacy of presentation Full colour throughout with 700 illustrative figures Wide faculty of international contributors Sherlock's Diseases of the Liver and Biliary System, 13th Edition is an ideal primer in hepatology for students and trainees in hepatology and gastroenterology, and a valuable resource for all specialist gastroenterologists and hepatologists, paediatricians, pathologists, radiologists, general physicians and specialist nurses.
Category: Medical

Nuclear Hepatology

Author : Gerbail T. Krishnamurthy
ISBN : 9783642006487
Genre : Medical
File Size : 54.77 MB
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Since the publication of the first edition of Nuclear Hepatology almost 10 years ago, new advances have taken place, both in our understanding of liver pathophysiology and various imaging modalities. A unique feature of imaging of physiology is that it enables quanti- cation. Since liver physiology is complex, quantification has been a challenge. Many p- lications in the past have often included quantification based on home-made software not available for others. Thus, the comparison of results from one center to another becomes difficult, if not impossible. The second edition of Nuclear Hepatology addresses these issues. Sophisticated software for liver and gallbladder function has been tested and va- dated through many of our previous publications. Now that software is FDA approved and available for others through a commercial company, it is hoped that future publications of imaging of liver and gallbladder physiology would routinely include quantification. Although the function of the hepatocyte is complex, it can be broadly divided into two main categories, substrate uptake at the basolateral border and intracellular transit prior to excretion into the canaliculi. The earliest manifestation of hepatocellular injury occurs in the form of prolongation of the intracellular transit time, which occurs long before the disruption of the basolateral border with subsequent rupture and death. The liver enzymes are released into circulation after the death of the hepatocyte.
Category: Medical

The Netter Collection Of Medical Illustrations Digestive System Part Iii Liver Etc E Book

Author : James C Reynolds
ISBN : 9780323389341
Genre : Medical
File Size : 70.11 MB
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Liver, Biliary Tract and Pancreas, 2nd Edition, part 3 in the 3-book Digestive System volume, provides a concise and highly visual approach to the basic sciences and clinical pathology of the hepatobiliary system and pancreas. This book in The Netter Collection of Medical Illustrations (the CIBA "Green Books") has been expanded and revised to capture current perspectives in hepatology, pancreatology, and gastroenterology - from normal anatomy and physiology through pathophysiology, diagnostics and treatment of the liver, pancreas, and biliary tract. It also features radiologic and pathologic images to supplement the classic Netter illustrations, as well as new illustrations. This this updated classic is ideal for students and health professionals seeking an easily accessible guide to the digestive system. Put concepts into practice. An exquisite art program that focuses on clarity of presentation with an emphasis on anatomy, pathology, patient presentation, and clinical context. Gain a rich, comprehensive overview of the liver, pancreas and biliary tract by seeing classic Netter illustrations side by side with cutting-edge radiologic and laparoscopic images. Explore key topics, including tumors of cirrhosis, portal hypertension, pancreatitis, liver lobectomy and transplantation, and cholescystectomy. See modern issues in digestive health and disease captured in the visually rich Netter artistic tradition via contributions from artists working in the Netter style. Get complete, integrated visual guidance on the hepatobiliary system and pancreas in a single source, from basic sciences and normal anatomy and function through pathologic conditions. Benefit from the knowledge of a team of renowned clinicians and scientists.
Category: Medical

Diseases Of The Gallbladder And Bile Ducts

Author : Pierre-Alain Clavien
ISBN : 9780470986974
Genre : Medical
File Size : 30.15 MB
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An interdisciplinary reference book for the diagnosis and treatment of gallbladder and bile duct diseases With recent developments in the management of hepatobiliary diseases including liver transplantation, this new edition aids all members of the team by addressing both the biliary indications for and biliary complications of these procedures. It's divided into three sections on anatomy, pathophysiology, and epidemiology; diagnostic and therapeutic approaches including the latest therapeutic modalities; and specific conditions. Includes more than 250 illustrations for rapid reference. Each chapter now has a Q&A section and begins with a list of objectives outlining the chapter’s goals. In addition, a number of new imaging modalities are presented in this new edition. It takes an integrated medical, surgical and radiological approach, making this invaluable to all members of the team who deal with complications of liver transplantation and the management of patients.
Category: Medical

Pet Ct In Hepatobiliary And Pancreatic Malignancies

Author : Nilendu Purandare
ISBN : 9783319605074
Genre : Medical
File Size : 41.68 MB
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This book is a pocket guide to the role of PET/CT in malignancies of the hepatobiliary system and pancreas. Imaging findings characteristic of malignancies are described and illustrated, and attention drawn to normal variants and artifacts. In addition, information is presented on epidemiology, clinical presentation, pathology, staging, and management in order to provide the clinical insight required by the imaging specialist. The book will be of immense value to practicing nuclear physicians as well as hybrid imaging specialists, particularly during reading sessions and multidisciplinary team meetings. It will also serve as a quick reference for residents and fellows in the PET/CT department. The book is published within the series Clinicians’ Guides to Radionuclide Hybrid Imaging, which is compiled under the auspices of the British Nuclear Medicine Society. The series is the joint work of professionals worldwide who share a common vision in promoting nuclear medicine as an important imaging specialty for the diagnosis and management of oncological and non-oncological conditions.
Category: Medical

Hepatobiliary Diseases Cholestasis And Gallstone

Author : M. Acalovschi
ISBN : 0792387708
Genre : Medical
File Size : 39.13 MB
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In recent years, our knowledge about the pathogenesis, pathophysiology and treatment of hepatobiliary diseases has increased considerably. The molecular basis of cholestatic disorders as well as of gallstone disease is increasingly recognized. This has resulted in improved diagnosis, for instance in hereditary forms of intrahepatic cholestasis, and advances in treatment, for example in primary biliary cirrhosis and other chronic cholestatic disorders. This book, the proceedings of a Falk Workshop held in Cluj-Napoca, Romania, on June 9-10, 2000, brings together contributions from scientists and clinicians to highlight the most recent advances in molecular biology, pathophysiology, diagnosis and therapy of diseases of the hepatobiliary system. World experts cover a broad spectrum of topics from genetic studies to endoscopy and from medical treatment to liver transplantation.
Category: Medical

Diagnostic Radiology Gastrointestinal And Hepatobiliary Imaging

Author : Arun Kumar Gupta
ISBN : 9789386261977
Genre : Medical
File Size : 26.53 MB
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The new edition of this comprehensive guide has been fully revised to provide clinicians with the very latest information and developments in the field of diagnostic imaging of the gastrointestinal and hepatobiliary system. Beginning with an overview of imaging techniques for the abdomen, the following sections discuss radiological methods for diagnosing different diseases and disorders in the bowel, liver, biliary tree, and pancreas. The final section covers miscellaneous topics including imaging in abdominal trauma, imaging of the spleen, imaging of the postoperative abdomen, and portal hypertension. Each case provides in depth coverage of all clinicopathological aspects with radiological correlation. The fourth edition of this atlas features nine brand new chapters including clinical and radiological aspects of ischemic bowel disease, liver transplant, malignant pathology of the biliary tract, chronic pancreatic, and more. More than 1000 clinical images, diagrams and tables enhance learning. Key Points Fully revised, fourth edition presenting latest advances in diagnostic imaging of the gastrointestinal and hepatobiliary system Includes nine new chapters Features more than 1000 images and illustrations Previous edition (9788184484342) published in 2008
Category: Medical