Post Genomic Cardiology

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Post Genomic Cardiology

Author : José Marín-García
ISBN : 9780124046429
Genre : Science
File Size : 28.60 MB
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In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome,” comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs
Category: Science

Aging And The Heart

Author : José Marín-García
ISBN : 0387740724
Genre : Medical
File Size : 64.92 MB
Format : PDF, ePub
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In this book, the genetic and molecular basis of cardiovascular aging is examined in detail and a comprehensive assessment given of the bioenergetics changes occurring in human and animal models of cardiac aging. Both current diagnostic and future therapeutic modalities are presented, giving this book a dual-pronged approach. Cardiac aging, like aging in general, is a complex process involving numerous cellular and molecular changes. This book sheds new light on the phenomenon.
Category: Medical

Heart Failure

Author : José Marín-García
ISBN : 9781607611479
Genre : Medical
File Size : 39.57 MB
Format : PDF
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Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease. An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies. Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the molecular, genetic, biochemical and cellular techniques critical to understanding HF. Further chapters discuss cardiac remodeling, oxidative stress, and alterations in other organs and systems that are often associated with HF. This book thoughtfully evaluates current and forthcoming diagnostic techniques and therapies, pharmaceutical and pharmacogenomic-based individualized medicine, gene and cell-based therapies, and the search for new frontiers. Heart Failure: Bench to Bedside presents a clear view of up-to-date approaches to clinical diagnosis and treatment, as well as offering insightful critiques of original and creative scientific thoughts on post-genomic HF research.
Category: Medical

Transactions Of The Board Of Trustees

Author : University of Illinois (System). Board of Trustees
ISBN : UIUC:30112075238086
Genre : Education, Higher
File Size : 66.95 MB
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Category: Education, Higher

Proteomic And Genomic Analysis Of Cardiovascular Disease

Author : Jennifer E. Van Eyk
ISBN : UOM:39015061093830
Genre : Science
File Size : 55.14 MB
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This is the very first book to focus on this new approach that will eventually aid in developing new diagnostic markers and therapies for controlling and treating heart disease - the number-one killer in the industrialized world. Divided into two parts, the book describes not only the potentials, but also the limitations of these technologies. The editors, both well known within the scientific community, provide new insights into the biochemical and cellular mechanisms of cardiovascular disease, as well as covering the transition into clinical applications. In so doing, they highlight the various strategies and technical aspects so as to assist the growing number of researchers intending to utilize these approaches. The result is an excellent way of educating and informing graduate students, post-doctoral fellows as well as researchers in academia and industry about the latest developments in this area.
Category: Science

Malaria Parasites

Author : Andrew P. Waters
ISBN : UOM:39015060622969
Genre : Medical
File Size : 89.10 MB
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The completion of the Plasmodium falciparum genome sequence in late 2002 heralded a new era in malaria research. The search began in earnest for new drugs and vaccines to combat malaria, a disease which afflicts up to 500 million people worldwide and is responsible for the deaths of more than one million people each year. The new genomic data is aiding a greater understanding of the living parasite and its interaction with the insect vector and human host. In this book internationally renowned experts provide up-to-date reviews of the most important aspects of post-genomic malaria research. Topics covered include: the P. falciparum genome and model parasites, bioinformatics and genome databases, microsatellite analysis, analysis of chromosome structure, cell cycle to RNA polymerase I and II mediated gene expression, role of the nuclear genome, the parasite surface and cell biology, and much more. The book is essential to all researchers working in this highly topical field and is recommended reading for scientists in other areas of biology and medicine.
Category: Medical

Textbook Of Interventional Cardiology

Author : Eric J. Topol
ISBN : UOM:39015073911516
Genre : Medical
File Size : 32.84 MB
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Completely refocused and reorganized, the new Edition of this respected resource offers you comprehensive, detailed, up-to-date, and clinically oriented coverage on all aspects of interventional cardiology. Edited by the world's most prominent specialist and researcher and contributed by more than 75 leaders in the field, this 5th edition brings you practical, evidence-based guidance on treating a full range of coronary lesions. They discuss the very latest techniques, devices, and adjunctive therapies and provide critical appraisals of emerging therapeutic approaches. The new edition is now in full-color and features a DVD of video clips demonstrating coronary intervention procedures, three new sections, and a plethora of new chapters that address the hottest topics today. Includes new sections on Patient Selection, Big Artery Vascular Interventions, and Evaluation of Interventional Techniques to help you make better informed decisions. Features new chapters on Transradial Intervention, Late Thrombosis, Biodegradable Stents, Support Devices for High-Risk PCI: IABP, CPS, LVAD, Imaging with Intracardiac Intervention (TEE and ICE), Patient Foramen Ovale and Atrial Septal Defect, Left Atrial Appendage Closure, and Regulatory Issues to keep you up to date. Presents an expanded international authorship and 50% new contributors, bringing you fresh, new perspectives. Increases the clinical focus and incorporates numerous treatment algorithms for better patient care. Uses full-color throughout for the first time, providing you with exceptional visual guidance. Includes a companion DVD of video clips demonstrating challenging techniques and procedures so know exactly how to proceed.
Category: Medical

Neonatal Cardiology

Author : Michael Artman
ISBN : 0070070989
Genre : Medical
File Size : 48.37 MB
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* Provides a sound background in the basic mechanisms of congenital heart disease * Includes guidelines for evaluating newborns with suspected heart disease * Offers advice on treatment and drug therapy guidelines
Category: Medical

Clinical Applications Of Pathophysiology

Author : Valentina L. Brashers
ISBN : UCSD:31822034391987
Genre : Medical
File Size : 49.15 MB
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This practice-focused review guide and workbook covers 27 of the most commonly encountered health problems to outline the connections between pathophysiology, assessment, diagnosis, and management, with an emphasis on the clinical use of pathophysiologic concepts. Each chapter includes case studies to illustrate the application of pathophysiology principles to clinical situations with questions relating to patient history, physical examination findings, lab and diagnostic studies, therapies, and follow-up care. Each question is designed to promote clinical reasoning and a deeper understanding through application of the concepts presented. Information on differential diagnosis is included. Consistent presentation of each disease includes definition, epidemiology, pathophysiology, patient presentation (history, symptoms, and examination), differential diagnosis, keys to assessment, and keys to management. Algorithms are used to illustrate the sequential action of disease processes. Unique! Clinical link diagrams for each disorder clearly illustrate how pathophysiologic concepts play a role in patient care. Unique! Critical thinking questions in a fill-in-the-blank format in included for every case study to promote continual clinical reasoning based on the available data. Case studies give students the history, physical examination, lab and diagnostic test results, and course of treatment for a hypothetical patient. Up-to-date bibliographies provide reading lists of the most important and current research published on each disease. Perforated pages allow students to fill out the answer spaces in the case studies and turn them in to their instructors for evaluation. Suggested answers with rationales to case study questions are available to instructors who require the book, to facilitate the use of the cases as class assignments. Table of laboratory test values for quick reference.
Category: Medical

Genome Research

Author :
ISBN : NWU:35558005623976
Genre :
File Size : 72.46 MB
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Author :
ISBN : NWU:35558005566910
Genre : Respiratory therapy
File Size : 69.42 MB
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Category: Respiratory therapy

P5 Medicine And Justice

Author : Santo Davide Ferrara
ISBN : 9783319670928
Genre : Medical
File Size : 31.73 MB
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This book describes the state of the art and future prospects of the most important bio-medicolegal subdisciplines in the post-genomic framework of personalized medicine. Focusing on the three main themes Innovation, Unitariness and Evidence, the book addresses a wide range of topics, including: Bio-Medicolegal and Criminological Sciences, Forensic Pathology and Anthropology, Clinical and Forensic Medicine in Living Persons (from Interpersonal Violence to Personal Injury and Damage, Malpractice, Personal Identification and Age Estimation), Forensic Genetics and Genomics, and Toxicology and Imaging. The unitariness of the “Bio-Medicolegal Sciences”, historically founded on the accuracy and rigor of the methods of ascertainment and criteria of evaluation, should be re-established on the basis of molecular evidence, and used to promote Personalized Justice. Taken together, the book’s conclusions and future perspectives outline a vision of transdisciplinary innovation and future evidence in the framework of personalized justice.
Category: Medical

Benn S Media

Author :
ISBN : UOM:39015057970967
Genre : Mass media
File Size : 29.66 MB
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Category: Mass media